After intensive preparation, the remarkable journey begins. Reza and Pip live with the Tembe tribe, whose land is under threat from illegal loggers, pass the controversial Belo Monte mega-dam, and pay a visit to a gold mine, where the situation suddenly become life-threatening.

Reza and Pip reach the land of the Munduruku: an indigenous community fighting the destruction of the Amazon. When lookouts spot a barge with illegal gold miners in the area, the pair join the tribe’s chief to confront the intruders, and soon realise that coming here may have been a grave mistake.

Travelling deeper into the heart of the Amazon, Reza and Pip learn how cattle ranching can either destroy or sustain the rainforest. When they find themselves in a caiman reserve, Pip joins a hunt in a rickety local boat, and soon becomes trapped in a terrifying situation.

The intensity of the journey builds, and Pip suffers an emotional breakdown. The pair cross into Peru to visit an eco-tourism lodge, which offers a promising vision of the Amazon’s future. The lodge helps Pip recuperate, until one of the locals reveals his tragic and heartbreaking life story.

Reza and Pip take a dangerous river trip into the interior of the Amazon to find pristine virgin forest, remote wildernesses free from roads and loggers and cattle ranchers, and some of the most isolated tribes in the world.

The conclusion of the journey beckons, but first Reza and Pip must cycle up and over the Andes. The punishing inclines and extreme altitudes cause tempers to flare, and the resulting nasty arguments push Pip into reckless behaviour on the dangerous roads.